Centre de Formation et d’Exploration Fonctionnelle PRIMates (CE2F-PRIM)

CE2F-PRIM (Centre de Formation et d’Exploration Fonctionnelle sur modèle PRIMates non humains) (UMS 3537-CNRS) is an unique structure in France and Europe, for its functional exploration of non-human primates (NHP), specifically in neuroscience, and for its training activities in animal testing.

Among its scientific and operational objectives, CE2F-PRIM wants to implement a structure for the production of neurological disease animal models by conventional and molecular approaches, in response to the limitations of mouse models. In association with the “Institut des Neurosciences de la Timone” (UMR7289) and the Station of Primatology (SdP) in Rousset, CE2F-PRIM is setting up a complete chain for the use of NHP model in biomedical research ranging from resource management to multi-modal functional testing (electrophysiology, in vivo multi-scale imaging). The center provides support to basic, clinical or private research (Biotechnology, CRO ...).

With more than 30 weeks of training per year, including all regulatory trainings in animal testing, thematic trainings on various animal models and on surgery models, CE2F-PRIM is one of the most important training center in animal testing in Europe.

Through SdP, CE2F-PRIM participates to the activities of EUPRIM-Net II Project. This Project links nine European primate centres in order to combine their wide range of biological and biomedical R&D activities, their extensive knowledge and infrastructure resources, as well as their solid experience in primate housing and breeding.

  • Hosting of non-human primates (Macaca mulatta, Macaca fascicularis, Saimiri sciureus) in outdoor parks or indoor animal housing
  • Trainings in animal testing (non-human primates, rodents, pigs)
  • Services to biotechnology companies and to academic units
  • Support to academic research teams through its surgical platform and its hosting structures
  • Functional exploration in monkeys :
    ◊ Neurosurgery
    ◊ Invasive and non-invasive techniques to decode brain activity
    ◊ Mass electrophysiology
    ◊ Molecular imaging (PET/SPECT), microscopic (confocal, two-photon), mesoscopic (optical), macroscopic imaging (IRM 3T)
    ◊ Recordings studies of disturbances of the motor behavior and of perceptual functions

CE2F-PRIM organizes more than 30 weeks of training sessions for the CNRS, INSERM and private companies, (about 200 people trained in 2012) and wishes to give new impetus to its training courses in animal testing for scientific and technical staff, either academic or private. 

  • Organization of regulatory training in animal experimentation, conform to the requirements of the new European Directive 2010/63 (former levels I and II, and surgery).
    The objective is to acquire the mandatory qualification to practice animal experimentation in accordance with the transposition of the new European Directive 2010/63.

    ◊ Specific regulatory training for staff developing experimental procedures and projects (former level I)
    Training program for researchers and research engineers having a direct scientific responsibility for experimentation on animals
    Training courses are all taking place in Marseille:
    ▪ "CNRS formation entreprises" training course:
    From 1 to 9 June, 2015 (57 h)  
    Description of the CNRS training and registration
    ▪ Trainings exclusively limited to CNRS employees or non-CNRS employees working in a CNRS unit:
    From 6 to 17 October, 2014
    From 8 to 19 December, 2014
    Registration procedures for the trainings limited to CNRS units
    ▪ INSERM training course:
    From 16 to 27 June, 2014
    Description of the INSERM training and registration

    ◊ Specific regulatory training for staff applying experimental procedures to animals (former level II)
    Training program for staff required to directly participate to experimentation on animals (technicians)
    5-day training courses, all taking place in Marseille:
    ▪ "CNRS formation entreprises" training course:
    From 13 to 17 April, 2015  
    Description of the CNRS training and registration
    ▪ Trainings exclusively limited to CNRS employees or non-CNRS employees working in a CNRS unit:
    From 20 to 24 October, 2014
    Registration procedures for the trainings limited to CNRS units
    ▪ INSERM training course:
    From 10 to 14 February, 2014
    Description of the INSERM training

    ◊ Specific regulatory training for animal care staff in charge of housing, maintenance and care of animals (former level III)
    5-day training course (exclusively limited to CNRS employees or non-CNRS employees working in a CNRS unit):
    From 22 to 26 September, 2014, Marseille
    Registration procedures for the trainings limited to CNRS units

    ◊ Specific regulatory training in surgery for staff applying experimental procedures to animals
    Training program for persons seeking an authorization to perform experiments requiring surgery in accordance with the transposition of the new European Directive 2010/63.
    4-day training courses, all taking place in Marseille:
    ▪ "CNRS formation entreprises" training course:
    From 16 to 19 March, 2015 (for personnes having followed a regulatory training level I or II)
    Description of the CNRS training and registration
    ▪ Trainings exclusively limited to CNRS employees or non-CNRS employees working in a CNRS unit:
    From 15 to 18 September, 2014
    From 20 to 23 October, 2014
    From 17 to 20 November, 2014
    Registration procedures for the training limited to CNRS units

  • Journées du Réseau des Zootechniciens du CNRS (ReZooTech) - Zootechnician network meeting of the CNRS
    Trainings are exclusively limited to CNRS zootechnicians or non-CNRS zootechnicians working in a CNRS unit
    From 18 to 20 November 2014, Marseille
    The program currently in progress will focus on the regulatory changes in accordance with the new European Directive 2010/63.

  • Acute Neurological Injury Training on rodent model
    Training organized in collaboration with the company NSRepair
    From 1st till 6th June, 2014, Marseille

    Description of the training and registration
    The training topics are the regulatory oversight in surgery, the animal and instrument preparation and surgical approaches of brain, brain vessels, spinal cord, peripheral nerves. 
    Application to models of stroke, ischemia, spinal cord injury, peripheral nerve injury.
  • European Surgical Training for the Utah Electrode Array
    Last session: 25-27 November 2013, Marseille
    Next session on 2014: dates not yet determined, Marseille

    Training organized in collaboration with the american company Blackrock Microsystems on multielectrode arrays.
    The purpose of this training is to familiarize the participants with the special skills needed for a successful Utah Array™ implantation surgery in non-human primates.
    Description of the 2013 session
  • Technical training on models of aquaculture
    From 8 to 12 September, 2014, Marseille
    ① General principles of fish biology (zebrafish, trout) and amphibians (Xenopus)
    ② Zootechnics, implementation and management of an aquaculture animal facility
    ③ Practical works in breeding, animal handling, anesthesia, euthanasia, marking and pathological anatomy
    ④ Infectious diseases and health status, study of diseases of farmed fishes and amphibians
    ⑤ Animal transport regulation and import of aquatic vertebrates
    RegistrationDescription of the 2013 session

  • Functional exploration in neurosurgery on non-human primates (NHP) and rodent models, to decode brain activity and its links with behavior
  • Development of a two-photon microscopy system in NHP models
  • Development of anatomical and functional imaging  by IRM 3T on a NHP model
  • Production of NHP models for neurological and psychiatric disorders

CE2F-PRIM logoMarseille

CE2F-PRIM logoNon-human primates, rodents

CE2F-PRIM logodata not available

top