Simian Laboratory Europe (SILABE)

The SILABE platform (Simian Laboratory Europe) was created in January 2011, on the location of the Center de Primatology (University of Strasbourg) supporting academic research on behaviour and cognition of non-human primates (NHP). SILABE provides several services on non-human primate models to health and pharmaceutical industries and academic laboratories.

SILABE can host 1600 primates on a 7 ha site with housing infrastructures responding to European standards and offering an optimal environment in terms of animal welfare and scientific expertise. Nine species of non-human primates are represented, whose rhesus and cynomolgus macaques, vervets and marmosets, which are models used in biomedical research.  Groups of Tonkean macaques, capuchin monkeys and lemurs are dedicated to behavioural studies and comparative cognitive explorations.

The use of NHP in biomedical research is justified in the studies of human diseases, to learn more about their causal pathways, their development, their infectiveness and to develop therapeutic and preventive strategies.

A quality management system insures the adequacy of products and services proposed by SILABE, according to the ISO 9001 standards. The plaform is certified ISO9001 2011.

Through the Center of Primatology in Strasbourg, SILABE is involved in the activities of EUPRIM-Net II Project. This Project links nine European primate centers in order to combine their wide range of biological and biomedical R&D activities, their extensive knowledge and infrastructure resources, as well as their solid experience in primate housing and breeding.

Since 2011, a quality management system has insured the adequacy of products and services proposed by SILABE to users' expectation according to ISO 9001 standards. Silabe/CDP is certified ISO 9001:2015 and has been accredited by AAALAC in 2014, with a recertification in 2017.

Hosting and distribution of non-human primates

  • Production, hosting and supply of non-human primates (NHP): Cynomolgus monkey, Rhesus monkey, Marmosets, vervet monkey
  • Import of NHP and quarantine
  • Care of retired animals
  • Supply of biological samples (blood, plasma, bone marrow, cerebrospinal fluid, serum, unrine, tissues, organs)

Customised studies

  • In vivo studies:
    ◊ surgery
    ◊ clinical biology
    ◊ histology / histochemistry
    ◊ imaging
    ◊ ophtalmology
    ◊ reproduction
  • Preclinical exploratory studies for health industries

Trainings in primatology

  • Pain management
  • Use of primates in biomedical research
  • Management of behaviour, environment and stress of primates in captivity

Trainings specific to non-human primates

All trainings are made in collaboration with the Center of Primatology and the service of continuing education of Strasbourg University. SILABE proposes trainings dedicated to staff working with non-human primates (NHP).

  • Pain management of the primates
    This module focuses on the comprehension of pain and suffering of primates kept in captivity for scientific purposes and their reduction. It responds the regulatory requirements of continuing education according article 5 of the French Ministerial Decree of 01/02/13 in respect of the acquisition and validation of staff expertise in user establishments, breeders and suppliers of animals used on a scientific purpose.
    This training is intended for researchers, vets, zootechnicians, ethical committee members, welfare structures members and generally speaking for all users of primates in the fields of biomedical research.
    After completion, the trainee will be able to express the concept of pain in physiological terms, to identify the signs of pain, to evaluate the degrees of severity, to define the endpoints, to implement solutions and protocols for pain treatment.
    Topics are:
    ① Physiological mechanisms of the pain
    ② Recognition of the signs of stress, distress, pain and suffering specific to primates
    ③ Use of adapted endpoints
    ④ Management of the pain, its prevention, medical and environmental treatments
    ⑤ Anesthetic and analgesic protocols
    ⑥ Methods of euthanasia
    Training in collaboration with the University of Strasbourg: 3 days
    ▪ Session in Niederhausbergen (outskirts of Strasbourg) in 2018: June 11-13
    Description
  • The primate in biomedical research
    Training intended for researchers, vets, zootechnicians, and generally speaking for all users of primates in the fields of biomedical research.
    Aims off the training:
    ① To address the non-human primate model in research according the new European recommendations and according the project
    ② To better understand physiological and behavioural needs, NHP diseases, for a better management of their health and welfare in animal facilities
    ③ To detect the signs of stress, distress and pain and to implement appropriate solutions
    ④ To analyse NHP with exploratory technics in the respect of 3R rules
    Training in collaboration with the University of Strasbourg: 5 days
    ▪ Session in Niederhausbergen (outskirts of Strasbourg) in 2018: November 12-16
    Description

 

  • Managing behaviour, environment and stress of non-human primates in captivity
    Training intended for researchers, vets, animal facilities managers, zootechnicians, and generally speaking for all users of primates kept in captivity.
    The aim is to acquire tools to optimise the welfare of NHP kept in captivity, through the management of their environment and a better understanding of their behaviour and needs.

    This training is shared in three  workshops which can be attended separately :
    ① Management of the behaviour of primates in captivity : feeding, social organisation, dominance hierarchy, impact of captivity, ethology, tools to measure and understand their behaviour and their use to reduce stress during handling and to train primates to cooperate
    ② management of the environment of primates in captivity: social environment, physical environment, Gestion de l'environnement des primates en captivité : environnement social, environnement physique, enrichment of the environment
    ③ Management of the stress of primates in captivity : questions on stress, its origins, its measurements, its prevention, its identification, the resolution of behavioural problems, implementation of corrective actions
    Training in collaboration with the University of Strasbourg: 3 days
    ▪ Session in Niederhausbergen (outskirts of Strasbourg) in 2018: April 4-6 (Possible to attend 1 or 2 workshops out of 3)
    Description

 

  • The marmoset (Callithrix jacchus) in biomedical research
    The program of that training intended for researchers, vets, zootechnicians, and generally speaking for all users of primates in the fields of biomedical research, can be adapted to the demand.
    Aims of the training
    ① To be aware of the behavioral and biological characteristics (anatomy, physiology, immunology, reproduction ...) of marmosets.
    ② To learn procedures adapted to hosting, husbandry, feeding, care and health status of marmosets.
    ③ To get familiar with the techniques of handling and investigation in an experimental context.
    ④ To understand how to use marmoset model in research by a good knowledge of its peculiarities
    Training in collaboration with the University of Strasbourg
    ▪ Training on demand, Niederhausbergen (outskirts of Strasbourg)

Contribution to regulatory trainings

The objective is to acquire the mandatory qualification to practice animal experimentation in accordance with the transposition of the new European Directive 2010/63.

  • Contribution to the regulatory trainings to use "rodents" for staff developing experimental procedures (formerly level I)
    A 57-hour training program (a 25-hour basic module + a 32-hour specialized module) for researchers and engineers having direct scientific responsibility for experimentation on animals .
    "CNRS formation entreprises": 7 days
    ▪ Session in Gif-sur-Yvette in 2017: November 13-17.
    Description of the training

    Trainings exclusively limited to CNRS employees or non-CNRS employees working in a CNRS unit: 7 days
    ▪ 4 sessions in Paris in 2017: March 13-21, May 15-23, September 25 to October 3, November 27 to December 5.
    Registration
  • Contribution to the regulatory trainings to use "rodents" for staff applying experimental procedures (formerly level II)
    A 45-hour training program (a 13-hour basic module + a 32-hour specialized module) for staff required to directly participate to experimentation on animals (technicians).
    "CNRS formation entreprises" in Gif-sur-Yvette in 2017 (5 days): April 24-28, June 12-16, November 6-10.
    Training description

Customised trainings

  • SILABE organises customised trainings on demand

Hosting of students

  • SILABE welcomes, under convention, students with various curriculum

Zootechny

  • Nutrition
  • Reproduction
  • Enrichment
  • Training of primates to cooperate

Functional exploration of non-human primates

  • Behavioural assays on groups living in semi-wild areas
  • Development of exploratory tools for primates (telemetry, imaging, neurocognition assays, videotracking).
  • Comparative testing by software on aging

Metabolic diseases

  • Creation of NHP models for drug testings in collaboration with the University of Strasbourg
  • Natural observations of obesity and molecular assays

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