News archive

Announcement Preparation of murine embryonic stem cells lines (mESC) June 28, 2017

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The goal of this protocol (written in French) is to describe the steps and quality controls to prepare new stable murine embryonic stem cells lines :

① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse line
② or from genetically modified mouse embryos with two aims :

  • to make a in vitro phenotypic analysis of the cells from the differentiation of these embryonic stem cells
  • to introduce new mutations into these mutant embryonic stem cells and thus create multitransgenic animals

Event 2nd European school in mouse phenogenomics May 19, 2017

June 12 - 16, 2017 Related link


Good practices: use of mouse models for biomedical and scientific research

Would you like to learn how to choose, create and analyze your best mouse model? Do you have a sufficient background in mouse functional genomics to lead at best your research?
This international training of excellence provides engineers, PhDs and researchers with an innovative program focused on best practices in the use of the mouse model biomedical and scientific research. Reach us and you will gain crucial skills required to use as best mutant mice and support you in your research!
It provides a wealth of information on good practices in the use of mouse model (standardized techniques, ethics, regulations, analysis, data and resources ...) to support attendees in their research.
The training takes place in Goersdorf-Liebfrauenberg (North of Alsace, France) from June 12 th to 16th.

Announcement Stop Vivisection: the Mediator confirms the answer of the European Commission May 19, 2017

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The initiative European Citizen Stop Vivisection asked to the European Commission for the abrogation of the directive 2010 / 63 / EU on the protection of animals used to fine scientists and the commitment of a process of abolition of the use of animals in scientific research.
The Commission had answered that: i) the scientific knowledge need animal research, ii) animal experiment remained important for the protection of the human and animal health,  and to protect the environment, iii) the commission did not intend to repeal the current directive.
The organizers of the initiative had requested a complaint with the European Commission against this answer.
The Mediator led investigation and observed that the Commission had explained in a clear, understandable and detailed way its position and its political choices and that it had introduced a series of actions in answer to the initiative.
The Mediator concludes in its report dated April 18th, 2017 that the Commission had answered according to the spirit and to the logic of the rules of the Initiative European Citizen and that no administrative fault could be raised against it.

Project Call Call 2016: ‘Mouse Models and Rare Diseases’ Jan. 16, 2017

Deadline: Feb. 9, 2017 Related link

The French Foundation for Rare Diseases (Fondation maladies rares) and the French National Infrastructure PHENOMIN are pleased to launch their 3rd joint call for the creation and exploration of mouse models for rare diseases.
The French Foundation for rare diseases (Fondation maladies rares) and the French National Infrastructure PHENOMIN are pleased to launch their 3rd joint call for the creation and exploration of mouse models for rare diseases.

The call for projects 'Mouse models and rare diseases' aims to give a significant boost to the development of mouse models, in order to:

  • gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified;
  • test and validate therapeutic proofs of concept, at the pre-clinical in vivo level.

This call aims to create and caracterise consitutive (Ko) and conditional Knock-Out (cKO), Knock-In (KI) and transgenic (TG) mouse models in the field of rare diseases.

Indeed, producing these models meets a key objective in the development of a therapeutic strategy. After their initial in vitro testing, therapeutic proofs of concept must be tested in a living model that recapitulates as closely as possible both the phenotype and biological defects associated to the human disease. Such a model should provide appropriate data regarding the safety and the efficiency of the drug, thus evaluating its benefit/risk ratio, prior to conducting early phases of a therapeutic trial. PHENOMIN and the French Foundation for rare diseases combine their efforts in order to achieve these objectives through the joint call for proposals for the generation and characterization of mouse models, dedicated to rare diseases.

Upload the call fo proposal
Submission on line
Submission deadline for proposals: February 9, 2017, 5:00 pm

Announcement CRISPR/Cas 9 frequently asked questions Jan. 15, 2017

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CELPHEDIA WP1 workgroup gathers experts using CRISPR/Cas9 system in various animal models including mouse, rat, zebrafish and drosophila. By sharing our knowledge, experience and an extensive bibliographic review, we have worked together to write some recommendations for CRISPR/cas9 system. Our goal is to help scientists who want to use this technology for gene editing by summarizing current advances on many technical aspects, from the RNA guide optimized design to the genotyping analysis and the validation of the newly generated models.

Announcement In vivo CRISPR-Cas9 genome editing Jan. 14, 2017

March 9 - 10, 2017 Related link

This training given in English aims to provide a general framework to get scientists started using CRISPR/Cas9 for in vivo gene editing in rodents. It will include lectures, practical workshops and interactive discussions. The training is open to graduate students (PhD), post-doctoral scientists, researchers and engineers.
The main topics are:
① Learn more about gene editing and how it works
② Hear about current advances on many technical aspects
③ Optimize the RNA guide design to the genotyping analysis (Bioinformatics workshop)
④ Highlight crucial issue in your own scientific project
Training "CNRS formation entreprises" in Illkirch (outskirts of Strasbourg)

Congress Transgenic_rat_meeting Jan. 12, 2017

May 11 - 12, 2017 Related link

This meeting is  organized by the “Transgenic rats” core facility, SFR François Bonamy, Biogenouest, TEFOR and IBiSA. The quality of the speakers is of the highest international level. The meeting will give the opportunity to update information on techniques and models in transgenesis and genetic engineering. It is intended for Master, PhD and medical students with a background in molecular biology and genetics as an introduction to future work in these rapidly developing areas of research. It is also intended for post-docs and scientists already working in certain of these fields and who are interested in expanding their knowledge on the potential applications of these new techniques to their models or in neighbouring pathophysiological models of analysis of genes or diseases using genetically modified animals.

Announcement Regulatory training in English Jan. 10, 2017

July 3 - 11, 2017

The training program of 57 hours (over 7 days) is designed for Anglophone students and researchers having a direct scientific responsibility for experimentation on animals.
The teaching will focus on regulatory and legislative initiatives in animal experimentation in accordance with European and national regulation. It will also provide basic knowledge on the handling and use of laboratory rodents (animal welfare, ethics, cognition and behaviour, pain and stress, anaesthesia, analgesia, euthanasia, pathologies, zootechnics, anatomy, physiology, genetic engineering, phenotyping, imaging, alternative methods, biostatistics), as well as the selection criterion of an animal model.
This regulatory training is organized by CE2F-PRIM and held with the collaboration and the assistance of all the partner centers of CELPHEDIA. It will take place on July 3-11, 2017, in Marseille and might be limited to non-Francophone students and researchers working in a CNRS unit.
To register, create an account on the link  Registration

Congress 8e colloque du Club des belles souris Sept. 23, 2016

Nov. 8, 2016 Related link

Nous sommes heureux de vous annoncer le 8° colloque du Club des belles souris qui cette année aura lieu le 08 Nov. 2016 à l’IGBMC, Strasbourg-Illkirch

Vous pouvez vous inscrire dès maintenant en utilisant le site web https://cbellessouris.sciencesconf.org/

Event Regulatory training in English May 26, 2016

July 4 - 12, 2016 Related link

The training program of 57 hours (over 7 days) is designed for Anglophone students and researchers having a direct scientific responsibility for experimentation on animals.
The teaching will focus on regulatory and legislative initiatives in animal experimentation in accordance with European and national regulation. It will also provide basic knowledge on the handling and use of laboratory rodents (animal welfare, ethics, cognition and behaviour, pain and stress, anaesthesia, analgesia, euthanasia, pathologies, zootechnics, anatomy, physiology, genetic engineering, phenotyping, imaging, alternative methods, biostatistics), as well as the selection criterion of an animal model.
This regulatory training is organized by CE2F-PRIM and held with the collaboration and the assistance of all the partner centers of CELPHEDIA. It will take place on July 4th-12th 2016, in Marseille and might be limited to non-Francophone students and researchers working in a CNRS unit.
To register, create an account on https://formations.primato.cnrs.fr/createAccount.php
Send all enquiries to formation-experimentation@ipbs.fr

Congress 2016 IMPC-INFRAFRONTIER meeting March 30, 2016

April 20 - 22, 2016 Related link

Investigating mouse models for biological for research

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about “Animal models for human diseases” and recent developments in mouse models phenotyping imaging.

We count on the attendance of 200 total participants every day including researchers of regional, national, European and international prominence and IMPC members and funders. The IMPC congress will be held on April 20-22, 2016 in Illkirch, France.
Description of the meeting
Detailled program

Project Call PHENOMIN 6th call results Feb. 4, 2016

The National Infrastructure PHENOMIN is pleased to announce the results of its 6th Call: Generation and Characterization of CreERT2 cell specific promoter driven deleter mouse lines. The Scientific Committee has selected 13 projects amongst 34 submitted projects from 20 PI. Consequently, 9 additional CreERT2 mouse lines will be generated by PHENOMIN team and will be made available as soon as possible for the scientific community. 4 CreERT2 mouse models been already generated by the European EUCOMMTOOLS consortium, will be further characterized.

You will find the details of the selected models on: http://www.phenomin.fr/calls/current-call/#phenomin-6th-call-results

To get more information, contact mutagenesis@igbmc.fr

Congress "Microbiota and animal model" meeting Feb. 3, 2016

March 15, 2016 Related link

A "Microbiota and animal model" meeting is organized by the National Infrastructure PHENOMIN in Orléans on 2016, March 15th.
It has been proved that microbiota has a strong impact on development and human health. The studying methods of these bacterial populations and their interactions with host cells are in a process of development. Some methods focus on animal models enabling to compare the impact of various monitored flora on the phenotype or to measure this impact according the genotype of modified animals.
With input from experts, the goal of this meeting is to overview the current studies of the microbiota and its interaction with the host. It is also an opportunity to visit a rodent animal facility with more than 10 years of expertise in maintaining genetically modified animals with a monitored flora.
Program & Registration

Meeting 7th annual meeting of EFOR network Feb. 2, 2016

March 7 - 8, 2016

The EFOR network is delighted to announce its 7th annual meeting in Paris on 2016, March 7th and 8th!
Thematic sessions will be held on the first day (March 7th): Models for studying stem cells from different tissues.Models for studying cerebrovascular accident. New imaging technologies and data processing tools. Genome editing in animals: ethical questions
The second day (March 8th) is devoted to parallel workshops, each dedicated to a model or a class of models: zebrafish, nematods, non-human primates, avian models, marine metazoa, lepidoptera, arthropoda, drosophila.
Preliminary program

To register, please contact djian@inaf.cnrs-gif.fr

Congress CTLS 2016 - Core Technologies for Life Science Jan. 30, 2016

June 12 - 15, 2016 Related link

CTLS 2016, organized by EMBL, aims to bring together not only scientists, technicians and managers, but also decision makers and opinion leaders involved in Core Technology facilities and resource laboratories in all fields of Life Science.
Building on the success of CTLS 2014 in Paris, this meeting will be a unique opportunity to listen and discuss with colleagues and peers about challenges and solutions on all scientific, technological, managerial funding, educational and community building aspects of core facilities and infrastructures.
Keynote lectures will provide the big picture of this dynamic field, complimented by five plenary sessions comprising both oral and poster presentations, which will allow presenters and attendees to explore and discuss issues concerning European core facilities and infrastructures. There will also be ample opportunity for existing and prospective core facility networks or interest groups to organise satellite meetings.

CTLS meeting will be held in EMBL Heidelberg, Germany on June 12-15, 2016

Detailed description
& registration

Meeting 14th COMTECH symposium 2016 Jan. 15, 2016

Jan. 28, 2016 Related link

ComTech is pleased to annouce his 14th colloque with the support of AFSTAL (french association for lab animal sciences and technics). It will be held at the Cité Internationale Universitaire in Paris, on January 28th, 2016.

Congress Colloque 2015 de la LFDA "Le bien-être animal, de la science au droit" Dec. 4, 2015

Dec. 10 - 11, 2015 Related link

La Fondation Droit Animal, Éthique et Sciences organise un colloque international intitulé "Le Bien-être animal, de la Science au Droit", qui se tiendra à l'Unesco les 10 et 11 décembre 2015. Ce colloque fait suite à celui organisé en 2012 : "La Souffrance animale, de la Science au Droit".
Outre son objectif d’information du public sur les connaissances les plus actuelles sur le bien-être animal, ce colloque et ses conclusions pourraient appuyer les démarches que la Fondation Droit Animal, Éthique et Sciences conduit afin de renforcer et de préciser la législation et la réglementation visant à préserver le bien-être des animaux, tant auprès des pouvoirs exécutifs et parlementaires français que des instances européennes.

Une vingtaine d’intervenants des pays d’Europe, des Amériques, de l’Océanie, de l’Afrique et de l’Asie y seront conviés pour répondre à une série de questions concernant le bien-être animal sur 4 thèmes principaux :

  • Qu’est-ce que le bien-être animal ?
  • Prise en compte du bien-être animal par la législation dans le monde
  • Le bien-être animal face aux facteurs socio-économiques et culturels
  • Objectifs pour l’avenir

Project Call PHENOMIN 6th call for proposal Oct. 7, 2015

Deadline: Oct. 15, 2015 Related link

The new PHENOMIN call is dedicated to generation and characterization of CreERT2 cell specific promoter driven deleter mouse lines.

Since 2011, PHENOMIN has generated more than 150 models with conditional potential. In the frame of the International Mouse Phenotyping Consortium (IMPC) more than 5,000 genes are already committed to the IMPC pipeline. Most of these models can be driven in conditional alleles.

PHENOMIN aims to maximize the utility of this resource by offering the scientific community with the possibility to generate and characterize new Cre or CreERT2 lines.

In the last decade, PHENOMIN has generated and validated more than 30 cell specific inducible CreERT2 deleter lines (http://www.ics-mci.fr/mousecre).  It has written guidelines for using cre/lox system in mice (European FP7 CREATE program, http://www.creline.org/other_cre_db_resources). It has developed a highly efficient universal cre deleter line (http://www.ncbi.nlm.nih.gov/pubmed/22121025). As a partner in EUCOMTOOLS effort, we are establishing new 250 CreERT2 knock-in models (http://www.mousephenotype.org/about-ikmc/eucommtools) in a pure C57BL/6N background.

The call targets the French scientific community. It is a real opportunity to nominate new CreERT2 drivers with useful expression patterns. Projects will be selected on scientific bases and non-availability of similar Cre/CreERT2 lines available in other repositories. Proposals will be reviewed by a scientific committee.

To apply to this call, please fill in the application form

Application deadline is 15th of October 2015.

Congress ACD Symposium: The RNA revolution Sept. 28, 2015

Oct. 15, 2015 Related link


RNA expression reflects the state of a biological system, it presents an ideal choice of biomarker and has become a significant focus for research, diagnostic and pharmaceutical arenas.  In order to utilize the full potential of these biomarkers, there is an unprecedented demand for the next generation of more effective tools for routine RNA biomarker analysis. This demand is particularly acute when it comes to in situ techniques, in order to map important pathways and networks within the morphological context.

This symposium features discussions by scientists who have successful applied RNA ISH in drug and CDx development and clinical research. Presenters will share how their work has been impacted by a new dimension of information - gene expression with spatial resolution. They will also discuss how RNA ISH complements IHC and will present data obtained with automation system from Leica and Ventana.

We invite scientists from Pharmas, Biotechs and Academic labs who are applying molecular methods in disease research and interested in elevating their research with new RNA analysis technologies.

Announcement Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics July 28, 2015

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The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. This consortium developped new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power.

Phenotype data from 449 mutant alleles were acquired, representing 320 unique genes, of which half had no previous functional annotation and data from over 27,000 mice were captured, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, significant differences were found in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.

For more information, please consult online article on Nature Genetics.

Announcement European Animal research Association July 16, 2015

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The European Animal Research Association (EARA) is a communication and awareness organisation whose mission is to uphold the interests of biomedical research and healthcare development across Europe. Europe needed such a public information platform providing accurate and evidence-based information on the benefits of biomedical animal research. EARA has developed communication tools and a proactive collaboration with the media to inform, educate and unify audiences on the key issues. Thus, EARA facilitates the open debate on the use of animals in scientific research.
EARA also focuses on creating an international favourable climate for animal research, leading pan-European initiatives to assert the rights to use laboratory animals in research. EARA supports animal research facilities to access the goods and services needed to develop new medicines and treatments.
For more information, please consult EARA website.

Announcement New NIH policies for grants and funding. June 19, 2015

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The National Institutes of Health (NIH) is supporting scientists in the fundamental understanding and knowledge of living systems to improve the success of  applications towards human health. It has recently updated its policy regarding NIH-funded researches for applications submitted for the January 25, 2016 and beyond.
The new policy promotes the reproducibility of research findings through increased scientific rigor and transparency in funding applications. It  focuses on 4 criteria: “i) the scientific premise of the proposed research, ii) rigorous experimental design for robust and unbiased results, iii) consideration of relevant biological variable and iv) authentication of key biological and/or chemical resources”.
As well as age and genetic background, sex and gender may play a role in health and disease processes and they should be considered as critical to the interpretation, validation, and generalizability of research findings. The new policy of NIH application instructions will follow this consideration and is expecting that “sex as a biological variable will be factored into research design, analyses and reporting in vertebrate animal and human studies”.
For more information regarding NIH expectations, please consult

Announcement Mouse biobanks for scientific reproducibility, ethical and financial concerns. June 19, 2015

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In a recent article, Lloyd and colleagues argue that the use of centralized mouse repositories are essential. Today, whereas ethical and financial concerns as well as scientific reproducibility are at the heart of the Science, only 12% of mouse models are available from repositories and 55% have been engineered more than once by different research teams, wasting animals, time and money (NIH/Jackson laboratory data). Furthermore, repositories can help Science to move forward by ensuring quality and welfare of distributed animals and by supplying expertise to guide reliable studies. For more detailed information, please consult the website of Nature.

Announcement Communication of the European Commission on the 3rd European Citizen's initiative "STOP Vivisection" June 4, 2015

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The European Commission has issued a communication regarding the European Citizens’ Initiative “Stop Vivisection” which aimed to repeal to current European Directive 2010/63/EU (see our news published on  March 31, 2015).

In brief this initiative has been rejected by the EC and no changes would be applied to the actual legislation. In fact, despite the EC recognizes the concerns expressed by the proponents of this initiative, the Directive has been confirmed to be the best compromise between animal welfare enhancement and biomedical researches requiring animal experimentations.

For more information, please consult the European Commission conclusion on http://ec.europa.eu/environment/chemicals/lab_animals/pdf/vivisection/en.pdf

Announcement The animal research reporting of in Vivo Experiments (ARRIVE) guidelines ! May 27, 2015

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The Animal Research Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future.

More information on PLOS biology

Meeting Transgenic Rat Meeting Nantes May 21, 2015

July 2 - 3, 2015 Related link

This meeting is organized by the “Transgenic rats” core facility, SFR François Bonamy, Biogenouest, TEFOR and IBiSA. The quality of the speakers is of the highest international level. The meeting will give the opportunity to update information on techniques and models in transgenesis and genetic engineering.It is intended for Master, PhD and medical students with a background in molecular biology and genetics as an introduction to future work in these rapidly developing areas of research. It is also intended for post-docs and scientists already working in certain of these fields and who are interested in expanding their knowledge on the potential applications of these new techniques to their models or in neighbouring pathophysiological models of analysis of genes or diseases using genetically modified animals.

Program
Registration

Project Call 3rd Call fof joint research projects with IMPC May 20, 2015

Deadline: June 15, 2015 Related link

The National Infrastructure PHENOMIN PHENOMIN (CIPHE, ICS, TAAM) is pleased to announce the launch of the 3rd call for nomination in the frame of its partnership with the International Mouse Phenotyping Consortium (IMPC). This call for proposals is addressed to French-based research groups. It aims to establish and characterize mouse models: constitutive Knock-out (KO) and conditional Knock-Out (cKO). These knockout mice, together with the wealth of associated data, will serve as a valuable, freely available, resource for French researchers investigating gene function and human pathophysiology.

Since 2011, PHENOMIN has generated more than 150 models. In the frame of the IMPC more than 5,000 genes are already committed to the IMPC pipeline. Until the end of 2016, PHENOMIN will generate 100 additional knock-out lines. All these lines will be phenotyped through the standardized IMPC broad-based pipeline. Up to now, all models have been generated from ES mutant cells with conditional potential generated by the International Knockout Mouse Consortium (IKMC).

In the frame of this call, we have added constitutive knock-out models to be generated using CRISPR (clustered regularly interspaced short palindromic repeats) genome editing technology.

Conditions for eligibility:

  • For conditional and constitutive knock-out models: availability of at least 3 ES mutant cells with conditional potential generated by the IKMC consortium.
  • If no ES cells or less than 3 clones are available within the IKMC consortium, only the constitutive knock-out model will be generated using CRISPR genome editing technology.
  • To avoid any duplication within the IMPC, a gene already reserved by another center (i.e. already produced, or with production underway, or planned to be produced) will not be selected but the production state will be transferred to the requestor.

 

For all models that will be selected, please consider that:

  • As soon as the germ line transmission is confirmed, corresponding mouse lines will be available by the IMPC for your research as well as to any group which could be interested in.
  • The phenotyping data from comprehensive screen will be published on a public database and accessible to the whole scientific community.

To apply to this call for proposal, please fill in the application form.

Extended application deadline: June 15th, 2015.

Event Regulatory training in English May 4, 2015

Sept. 7 - 15, 2015

Regulatory training in ENGLISH for staff developing experimental procedures and projects (former level I)
The training program of 57 hours (over 7 days) is designed for Anglophone students and researchers having a direct scientific responsibility for experimentation on animals.
The teaching will focus on regulatory and legislative initiatives in animal experimentation in accordance with European and national regulation. It will also provide basic knowledge on the handling and use of laboratory rodents (animal welfare, ethics, cognition and behaviour, pain and stress, anaesthesia, analgesia, euthanasia, pathologies, zootechnics, anatomy, physiology, genetic engineering, phenotyping, imaging, alternative methods, biostatistics), as well as the selection criterion of an animal model.
This regulatory training is organized by CE2F-PRIM and held with the collaboration and the assistance of all the partner centers of CELPHEDIA. It will take place from September 7th-15th 2015, in Marseille and might be limited to non-Francophone students and researchers working in a CNRS unit.
To register, create an account on https://formations.primato.cnrs.fr/createAccount.php
Send all enquiries to formation-experimentation@ipbs.fr

Announcement Results for the 2nd Joint Call « Murine Models and Rare Disease » May 1, 2015

The "Fondation maladies rares", in partnership with the national infrastructure PHENOMIN, supports research projects dedicated to the development and to the study of murins models in the field of the rare diseases.

This joint call for projects "Mouse models and rare diseases" aims to give a significant boost to the development of mouse models, in order to :

  • gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified

  • test and validate therapeutic proofs of concept, at the pre-clinical in vivo level

This 2nd joined call supported the creation and the characterization of murins models of rare diseases: Knock-Out constitutive (KO)/ conditional (cKO), Knock-In (KI) and transgenic mice-.

The ad hoc Scientific Committee has supported 13 research projects.

Congratulations to the laureates !

Congress Symposium SFDP: When primates communicate April 25, 2015

Oct. 14 - 16, 2015 Related link

SFDP, the French Society of Primatology will organize a symposium held at the University of Strasbourg from the 14th to the 16th of October 2015. The theme will be: When primates communicate.
The goal is to keep you aware of the progress in primatology research and to communicate on your own work.
A summary informing on the main subjetcs will be online soon.
If you wish to deliver a communication, submit that formular with an abstract before June the 30th and only by e-mail to: info@sfdp-primatologie.fr
Download the registration formular HERE

Meeting 7e Colloque du Club des Belles Souris April 17, 2015

Oct. 9, 2015 Related link

Institut Pasteur, Paris | October 9, 2015

The aim of the "Club des Belles Souris" is to generate scientific exchanges about techniques and technologies in mouse molecular genetics.
The scientific program of that 7th edition is of an outstanding quality thanks to French and foreign speakers who have recently made major and innovative contributions to transgenesis and phenotyping.
We strongly invite all partners involved in the generation and the analysis of mouse models to attend this conference. It is intended for researchers, graduate and post-doctoral students, as well as the staff involved.
This conference will also be an occasion to mark the 20th anniversary of the course given by Institut Pasteur on Mouse Genetics since 1995.

Admission is free but registration is mandatory on curie.fr/cbs2015

Event European advanced school for mouse phenogenomics April 14, 2015

June 8 - 12, 2015 Related link

PHENOMIN offers an international and first class 4-day session training to provide engineers (Master’s degrees), PhDs and researchers with a wealth of information about the good practices regarding the use of mouse models in biomedical research. The topics of mouse genetics, mutagenesis, phenotyping, mouse colony management, conservation and distribution of genetically modified mice will be covered. It's a unique opportunity to share knowledge and transfer new concepts and innovative methods.
37 experts, whose European speakers involved in INFRAFRONTIER Mouse clinics, will share with you all the new approaches that will profoundly change the basic, preclinical and biopharmaceuticals researches.

The training takes place in Liebfrauenberg (North of Alsace, France) from June 8th to 12th.

Objectives of the course:

  • Accelerate the sharing of conceptual scientific advances, and all the new approaches that will profoundly change the basic research, preclinical and biopharmaceuticals discoveries.
  • Transfer of technological knowledge ensuring the most effective experimental procedures in compliance with ethics and animal welfare for a successful use of mouse models.
  • Support attendees in use of European and international resources for mouse phenogenomics (cryopreservation, distribution and phenotyping data lines already characterized and available to the scientific community).
  • Help and advice attendees in their own research project through poster session, relevant work session on scientific and methodological issues, oral retransmission and personalized discussion with experts.
  • Address the issue of continuing professional education consistent with the new European directive requirements about regulatory training and lab animal experiments.

Social event: visits of wine cellars and tasting of regional products

Training program

Registration

Application dead line is approching: April 26th

Announcement STOP the European Citizens’ Initiative on Vivisection March 31, 2015

Related link

The European Citizens’ Initiative « Stop Vivisection » calls on the European Commission to repeal the European Directive 2010/63/EU on the protection of animals used for scientific purposes and to prohibit all research using animals in Europe.
This Directive has been shaped by consultation with animal welfare groups, scientists and animal technologists to ensure that necessary research involving animals can continue while requiring enhanced animal welfare standards. Since its application, the Directive led to the development of an ethical thought and to the enhancement of animal welfare in order to perform animal research in conditions that meet harm-benefice balance.
Good animal care and good science go hand in hand
Repealing this Directive would represent a major step backwards both for animal welfare in EU and for Europe’s leading role in advancing human and animal health. For reminder, the Directive allows the use of animals in research where the potential medial, veterinary and scientific benefits are compelling and there is no other viable alternative method.
We call the European Parliament and Commission to reaffirm their commitment to the Directive, essential to allow animal use for Research in a controlled and legislated environment.

For more information about Directive repealing consequences, please consult:
Statement supporting European Directive 2010/63/EU on the protection of animals used for scientific purposes
The League of European Research Universities (LERU) supports the Directive 210/63/EU

Meeting EUPRIM-Net: Long Term Development Meeting March 11, 2015

May 7 - 8, 2015 Related link

The genetic similarity between humans and nonhuman primates reflects not only in their resemblance in physiognomy and behavior, but also in their organ system functions or their nervous systems. That is why nonhuman primates provide models which are essential for research in genomics and biotechnology for health. The successful development of new strategies against human diseases like infectious (e.g. HIV, hepatitis) and neurological diseases (e.g. Alzheimer´s or Parkinson Disease) or cancer depends on the availability of living animals or biological material with primate origin. This also holds true for the development of new therapeutics (vaccines, gene therapy) and transplantation research.
The EU funded EUPRIM-Net links nine European primate centres in order to combine their wide range of biological and biomedical R&D activities, their extensive knowledge and infrastructure resources, as well as their solid experience in primate housing and breeding. The project covers the central aspects of primate research and is aimed at advancing knowledge and competence in the areas of research, animal keeping and breeding.

The next meeting will take place at DPZ, Leibniz, Germany, the 7 & 8 May, 2015

Announcement STOP the European Citizens' Initiative on Vivisection March 5, 2015

Related link

The League of European Research Universities (LERU) joins The Wellcome Trust in supporting European Directive 2010/63/EU and in calling upon the European Parliament and the Commission to reject the European Citizens' Initiative (ECI) Stop Vivisection which was submitted yesterday.
The ECI Stop Vivisection, which aims to prohibit the use of all animals in research, is based on flawed arguments, and if allowed to progress, could lead to the annulment of the 2010 EU Directive regulating the use of animals in research. This would be disastrous for Europe's research, as it would result in all such research being moved to other continents and putting Europe out of business in developing treatments for all kinds of diseases. Read the whole article

Off-grid training course Atelier Inserm 233: Intestinal microbiota: from bench to bedside Jan. 10, 2015

April 13 - 21, 2015 Related link

The workshop focuses on the current state of knowledge related to intestinal microbiota. This workshop targets microbiologists, bioinformaticians and physicians, in order to favor the translational applications of the gut microbiome studies.
The course will be held in two phases: Bordeaux: April 13-15, 2015 & Jouy-en-Josas (INRA) April 20-21, 2015
Program and registration
New registration deadline is February 6th, 2015

Congress EFOR seminar 6th edition Jan. 9, 2015

March 9 - 11, 2015 Related link

The EFOR network is delighted to announce its 6th annual meeting, organized in collaboration with the EMBRC-France infrastructure.

March 9th: four thematic sessions:
◊ Models for studying Ecology (EMBRC-France joint workshop)
◊ Models for studying neurodegenerative diseases 
◊ Calcium imaging
◊ CRISP-R/Cas9 system

March 10th: parallel workshops, each dedicated to a model or a class of models:
◊ Zebrafish
◊ Xenopus
◊ Non-Human Primates
◊ Farm mammals
◊ Marine Metazoa (EMBRC-France joint workshop)
◊ Arabidopsis thaliana and Friends
◊ Algae (EMBRC-France joint workshop)

March 11th: specific EMBRC-France workshop on Vibrio

Program
Registration

Project Call 2nd Joint Call "Fondation Maladies Rares - PHENOMIN" Jan. 5, 2015

Deadline: Jan. 13, 2015

The "Fondation Maladies Rares" and the National Infrastructure PHENOMIN (ICS, TAAM, CIPHE) are pleased to announce the launch of the 2nd call for joint research projects: "Mouse models and rare diseases".

This call for projects 'Mouse models and rare diseases' aims to give a significant boost to the development of mouse models, in order to :
◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified
◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level

Indeed, producing these models meets a key objective in the development of a therapeutic strategy. After their initial in vitro testing, therapeutic proofs of concept must be tested in a living model that recapitulates as closely as possible both the phenotype and biological defects associated to the human disease.
Such a model should provide appropriate data regarding the safety and the efficiency of the drug, thus evaluating its benefit/risk ratio, prior to conduct early phases of a therapeutic trial.
You can download the related documents from the website of the Foundation for rare diseases (http://fondation-maladiesrares.org) by registering / logging in professional area, Call Projects section or from the PHENOMIN website

Research projects must be submitted via filled application form no later than January 13, 2015 5:00pm

◊ by email at: modeles_murins@fondation-maladiesrares.com
◊ by mail: Fondation maladies rares, Appel à projets "Modèles murins et maladies rares", 96 rue Didot, Plateforme Maladies Rares, 75014 Paris

Each submitted form must be related to only one model.

We remain at your disposal for any further information and hope that you will respond to this call for many projects.
Wishing you every success in your projects.

Meeting IINFRAFRONTIER-I3 General Meeting Dec. 1, 2014

Dec. 9 - 10, 2014 Related link

INFRAFRONTIER-I3 General Meeting will be hold in Marseille, on December 9th-10th
INFRAFRONTIER aims to build a world-class research infrastructure that provides the biomedical research community with the tools needed to unravel the role of gene function in human disease.

The INFRAFRONTIER mission:
◊ to shape the European Research Area in the field of mouse functional genomics and thereby make an important contribution to the study of human disease.
◊ to set standards for systemic phenotyping of mouse models and for archiving and distribution of mouse mutants in Europe.
◊ to offer highest-quality services and cutting-edge technologies provided by the leading labs in Europe.
◊ to disseminate knowledge by state-of-the-art training courses.

Meeting ROCAD days 2014 July 20, 2014

Nov. 6 - 7, 2014 Related link

ROCAD is an operational French network which facilitates access and distribution of mouse models. It includes several national structures (research centers, laboratories or animal facilities) working together for many years. The aim is to standardize and optimize existing resources and skills using additional means, to the benefit of the scientific community. Like every year, the Work Packages will present the annual report of their results.
Plenary meeting 2014 will be held in Toulouse, on 6th and 7th November 2014.
More information on http://www.rocad.org/fr/meeting

Project Call IGFL: Call for New Research Group Leaders July 4, 2014

Deadline: July 4, 2014 Related link

The Institut de Génomique Fonctionnelle de Lyon (IGFL) currently hosting 13 research groups and having recently moved to multidisciplinary campus of Lyon-Gerland, is hiring new additional groups in line with its expansion. Research at IGFL focuses on the role of the genome in animal physiology, developmental biology and evolution. In addition, IGFL is actively seeking to strengthen its research in bioinformatics and modelling at the genomic scale.
IGFL groups have full access to state-of-the-art core services including high throughput sequencing technologies, X-Ray, microtomography, 2D and 3D imaging, morphometrics, transgenic animal facilities, bioinformatics, mass spectrometry, proteomics, FACS sorting, histology and electron microscopy. IGFL is searching for outstanding young scientists wishing to start their own team as well as established group leaders interested in joining the IGFL.
Group leaders with a strong interest in animal based research falling within the scientific mission of IGFL may apply to this call.
Further details on http://igfl.ens-lyon.fr/accueil/igfl/calls/2014CALLIGFL.pdf
The deadline is Friday July 4, 2014

Meeting Rehab 2014: Premières rencontres autour de la réhabilitation animale June 12, 2014

Deadline: June 20, 2014 Related link

Animals used in experimentation both in basic or applied research are euthanized over long term, either ending a protocol or being in excess. However an alternative to euthanasia exists: rehabilitation consisting in a retreat. Rehabilitation of laboratory animals apart from being ethical, can be a fabulous vehicle for communication and conciliation between scientists and the public. This idea of rehabilitation spreads in public, political and scientific areas. Nevertheless in France, neither a structure dedicated to laboratory animals retreat, nor competent staff do exist. Despite an active process, few researchers rehabilitate their laboratory animals.
The first meeting around animal rehabilitation is organized to invite all players in rehabilitation to introduce this ethical process to research institutes, scientific societies and ethics committees and to discuss its implementation in the near future.
The meeting will be held at the Collège Doctoral Européen in Strasbourg on June 20th, 2014.

Project Call Project call - Small animal models and rare diseases June 11, 2014

Deadline: July 18, 2014 Related link

The French Foundation for rare diseases (Fondation des maladies rares), in partnership with TEFOR infrastructure, launches its first call for research projects "Small animal models and rare diseases".
The objective is to support innovative projects dedicated to the development and the study of rare disease models using small animals (mouse model excepted) such as zebrafish, drosophila, nematode, rat and rabbit.
To carry out these projects, the teams will benefit of the latest techniques in genome editing provided by academic French platforms.
The deadline to submit the projects is on Friday July 18, 2014.
The terms of the call for proposals and the application form are available on fondation-maladiesrares.org, ‘professionnels’ area and on tefor.net/showcase2/pages/post.php?subject=events&id=251

Off-grid training course Aquatic models to foster innovation in biomedical research June 2, 2014

Deadline: June 27, 2014 Related link

Aquatic models are increasingly used in various biomedical contexts. One of the major goals of this course is to provide a large overview of the different approaches in aquatic organisms, at first hands in relation to immunology, degeneration/injury and regeneration.
The course will be held in two phases: Bordeaux: September 24-26, 2014 & Villefranche-sur-Mer / Roscoff: October 6-9, 2014
Information and registration Registration deadline is June 27th, 2014

Project Call Free of charge INFRAFRONTIER mouse phenotyping service for European researchers May 30, 2014

Deadline: June 30, 2014 Related link

The EC FP7 funded INFRAFRONTIER-I3 project supports European researchers with a free of charge mouse phenotyping service. A total of 22 mouse mutant lines can be characterised through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.
Information on  the  INFRAFRONTIER-I3 phenotyping service:
https://www.infrafrontier.eu/resources-and-services/free-charge-transnational-access-services/infrafrontier-i3-ta-mouse-0
The I3 Mouse Phenotyping TA Application form can be downloaded at the following address: https://www.infrafrontier.eu/resources-and-services/free-charge-transnational-access-services/application-pages Send your proposal to info@infrafrontier.eu by June 30th 2014

Congress Core Technologies for Life Science: CTLS 2014 May 4, 2014

June 2 - 5, 2014

CTLS 2014 is the first Pan-European Core Facility Congress dedicated to Core Facility Staff as well as other Life Science research staff.
The Congress will take place from 2nd to 5th June 2014 at the Institut Pasteur, Paris.
The program will run 3 parallel tracks:
◊ Research and Development with and within Core Technology Facilities
◊ Core Technology Facility management for long-term sustainability
◊ National and Trans-national Core Facility Networking
Workshops and some Satellite Meetings will be held on the 2nd, 5th and 6th of June.

Project Call INFRAFRONTIER-I3 project / Free of charge MOUSE PRODUCTION SERVICE / 3rd call April 30, 2014

Deadline: May 15, 2014 Related link

The EC FP7 funded INFRAFRONTIER-I3 project supports European customers with a free of charge mouse production service. A total of 30 KO mouse models will be produced by this service and will be made available to the wider community via EMMA.
The third call supporting the production of 10 KO models is now open.
Application forms can be downloaded from https://www.infrafrontier.eu/resources-and-services/free-charge-transnational-access-services/infrafrontier-i3-ta-mouse. Send your proposal to info@infrafrontier.eu by May 15th 2014

Announcement Results of PHENOMIN 3rd Call April 16, 2014

Related link

The National Infrastructure PHENOMIN is pleased to announce the results of the 3rd Call for Proposals 2013: Establishing and characterizing mouse models - conditional Knock-Out (cKO). The Scientific Committee has selected 45 projects amongst 98 submitted projects from 59 PI. Consequently, 45 additional new mouse lines will be generated by PHENOMIN team, in order to be available as soon as possible for the scientific community.
More information on http://www.phenomin.fr/calls/impc-2nd/

Meeting RAM-ROCAD days 2013 Oct. 24, 2013

Nov. 7 - 8, 2013 Related link

ROCAD network was created in 2006 to facilitate exchanges of animals and technologies between laboratories. It gathers several french structures (research centers, laboratories, animal facilities), either affiliated GIS-IBiSA or not, and working together for many years. The aim is to implement  a standardization and optimization of resource and existing expertise using complementary means, to the benefit of the scientific community. Every year, the network organizes a meeting to conduct a annual review of the different work packages.

Meeting Understanding the neural bases of diurnality June 18, 2013

Nov. 26 - 28, 2013 Related link

International meeting organized by Neurex and the Chronobiotron, a platform dedicated to the study of biological rhythms and specialized in breeding and analysis of nocturnal and diurnal rodent models.
In humans, disorders of rhythmicity may underlie a wide variety of medical conditions (obesity, diabetes, sleep and psychiatric disorders…) making the study of biological rhythms critical for human health and welfare. Up to now, studies using nocturnal rodents have provided most of our knowledge. Developing biomedical strategies to treat circadian clock disturbances in humans thus rely on diurnal models.
Registration:
http://diurnality.u-strasbg.fr/index.html

Congress 6th "Club des Belles Souris" Jan. 28, 2013

April 11, 2013 Related link

This edition will be held on April 11th in Montpellier. It is organized by Laurent Le Cam, Michel Cohen-Tannoudji, Yann Hérault, Holzenberger Martin and Lionel Larue.
Registration is free and mandatory : http://curie.fr/fr/6e-colloque-club-belles-souris-11-avril

Announcement New CELPHEDIA website June 6, 2012

June 6, 2012 Related link

The new CELPHEDIA website is now online ! It is available since June 6th 2012 and is now mobile devices compatible.

Congress 38th AFSTAL Conference Nov. 21, 2011

June 6 - 8, 2012 Related link

The 38th Annual Conference of the AFSTAL will be held from 6 to 8 June 2012 in Marseille. The AFSTAL will celebrate its 40th anniversary at the conference whose theme is largely dedicated to Quality.

Congress ComTech 2012 Nov. 21, 2011

March 8, 2012 Related link

The 10th Symposium ComTech will be held Thursday, March 8, 2012 at the Ecole Militaire in Paris 7th.

Off-grid training course Mouse Genetics Course Sept. 27, 2011

Related link

This course provides training in the most topical areas of mouse Genetics. It concentrates on analysis of gene function at all levels: the gene and its product, the cell and cellular interactions, embryonic tissues and the entire animal.

Meeting ILAF, ESLAV and ECLAM Joint Meeting May 25, 2011

Sept. 5 - 6, 2011

The scientific meeting, organized by ILAF, ESLAV and ECLAM, entitled: What’s New? Animals Models, Housing and Techniques will be held from September Monday 5th to Tuesday 6th, 2011 in Jerusalem, Israel.
Deadline early-bird registration: June 15, 2011

Meeting The ILAF-ESLAV-ECLAM joint annual scientific meeting May 24, 2011

Sept. 5 - 6, 2011

The ILAF-ESLAV-ECLAM joint annual scientific meeting entitled: "What's New? Animal Models, Housing and Techniques" will be held from September Monday 5th to tuesday 6th, 2011 in Jerusalem, Israel.

Deadline early-bird registration: June 15, 2011.

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