Objectives

Objectives specific to the Research Infrastructure

CELPHEDIA offers a better support for functional research in major model organisms. It is primordial to ensure preservation of the available models (e.g. mutant lines generated), as well as the experimental protocols used and the corresponding raw and analyzed data, in order to:

perpetuate the information and the knowledge about these models by having access to the raw data
decrease funding requests for the same models by promoting their analysis and storage in repositories and databases, and thus guarantee access to the scientific community for future scientific exploration
thereby reduce the number of animals used for experimental purposes and thus meet our society's concerns

CELPHEDIA is committed to achieve the three sub-objectives to strengthen fundamental, biomedical and pharmaceutical research.

Scientific objectives

1 - To provide and to develop innovative, standardized and massively parallel technological approaches, for the scientific community:

to accelerate the basic understanding of the genes and pathogenic variants involved in human and animal diseases
to promote therapeutic innovation through the validation of candidate genes as potential therapeutic targets and to determine their effects in referenced model organisms, particularly so-called humanized mice, and if required the non-human primate model.

2 - To favor translation of the results from a model organism to another.

3 - To perform a high throughput analysis of targets effects, either in normal or in pathological situations. Thus, a standardized functional exploration will be supplemented by more specialized analysis covered by all platforms, in connection with competitive research centers.

4 - To improve and standardize processes and protocols and thus facilitate national and international exchanges and access to the models of interest.

5 - To contribute to the international effort in the functional annotation of the genome and the understanding of human diseases.