Creation, Breeding, Phenotyping, Distribution and Archiving of model organisms

News

Translational Neuroscience Day
July 12, 2022

NeurATRIS “Translational Neuroscience Day” is back for its fourth edition on December 06, 2022, at the Cité Internationale Universitaire de Paris.

Co-organized with Celphedia, this new edition will be focused on animal models in neuroscience translational research and related hot topics.

 

Join us to learn more about current research in translational research, through 3 plenary sessions and 1 round table led by French key opinion leaders.

 

Take advantage of this day to interact with all key actors in the field: academic researchers, clinicians, biotech, and pharmaceutical companies.

 

Young researchers, do not miss the opportunity to highlight your work and submit an abstract to the “Next Generation Challenge”!

 

Registration opens on September 1th, 2022

More details on program and registration coming soon.

Dec. 6, 2022

https://translational-neuroscience-day-2022.b2match.io/

Transparency Charter in Animal Research in France: first assessment after one year
July 11, 2022

38 major players in research in France take stock of the first year of the implementation of the Transparency Charter on the use of animals for scientific and regulatory purposes.

38 major players in research in France take stock of the first year of the implementation of the Transparency Charter on the use of animals for scientific and regulatory purposes.

Why a Transparency Charter?

The use of animals in research is a complex and controversial subject. The scientific community is now aware that the general public needs to be informed about why and how animals are used in order to put an end to many preconceived ideas. In this context, the first Transparency Charter on the use of animals in research has been launched in February 2021. Its goal: communicating about animal research with the public.

The first charter report

Even if the pandemic situation has been an obstacle to carry out some communication actions, the 38 signatories of the Charter have assessed this first year of transparency. Among their conclusions, it is clear that this Charter has made it possible to enable the general public to understand the value of animal use and to improve the image of research.

https://www.gircor.fr/charte-transparence2022/

Transparency: Cédric Villani visits two Celphedia animal facilities for research in Strasbourg
March 13, 2022

Cédric Villani, député de l’Essonne et président de l’Office Parlementaire d'Évaluation des Choix Scientifiques et Technologiques (OPECST), a été invité à visiter et à rencontrer le personnel de...

Cédric Villani, député de l’Essonne et président de l’Office Parlementaire d'Évaluation des Choix Scientifiques et Technologiques (OPECST), a été invité à visiter et à rencontrer le personnel de deux animaleries de recherche situées près de Strasbourg (67).

A l'issue de ces visites, Cédric Villani a souligné l'importance des contrôles et des regards extérieurs. La composition des comités d'éthiques fait également partie de ses préoccupations. Il a particulièrement été marqué par l'investissement des professionnels avec lesquels il a pu échanger.

Feb. 11, 2022

https://www.gircor.fr/transparence-cedric-villani-visite-deux-animaleries-de-recherche-a-strasbourg/

6th edition of small animal imaging school, Toulouse
Feb. 22, 2022

The 6th edition of small animal imaging school is willing to consider all in vivo imaging modalities.....

The 6th edition of small animal imaging school, organized by Cancéropôle Grand Sud-Ouest, CREFRE-Anexplo and IPBS-TRI (GenoToul platforms), is willing to consider all in vivo imaging modalities (anatomical, functional and molecular) as well as longitudinal follow-up of animals.

More info

June 12, 2022 - June 16, 2022

http://imagerie.canceropole-gso.org/

ICS celebrates 20th anniversary
Feb. 21, 2022

FROM THE BEGINNING OF 2022, WE INVITE YOU TO CELEBRATE OUR 20 YEARS  !

The 20th anniversary of the ICS (Institut Clinique de la Souris) coincides with the 20th anniversary of the sequencing of the mouse genome!

Over the past 20 years, ICS has made significant contributions to the study of gene function and to innovations that have transformed the research landscape in this field. On this occasion, the entire ICS staff invites you to participate in meetings, exchanges, visits, workshops, webinars and debates.

We hope to give everyone the opportunity to exchange, including meeting our users and our partners and celebrate this anniversary together.

Jan. 1, 2022 - Nov. 18, 2022

https://ics-mci.sciencesconf.org/

IMPC 10 Year Celebratory Conference
Aug. 31, 2021

The IMPC is celebrating 10 years of research on mouse knockout production and phenotyping. We are hosting an array of exciting events such a monthly workshops, meetings and attending conferences.

A 2 day virtual meeting with international reach! International leading speakers from outside IMPC, as well as IMPC speakers, will reflect on the role of mouse genetics in biomedical research and genomics medicine, and the contributions of IMPC  to these achievements.

2 Day EventVirtual/ Conference – IMPC

Sept. 23, 2021 - Sept. 24, 2021

https://www.mousephenotype.org/about-impc/impc-10-year-anniversary/

3rd CCP Phenogenomics Conference
Aug. 31, 2021

The CCP Conference program and speakers have now been announced!

-Immunology, infectious diseases, and human diseases models.

-Preclinical development and advances in neuroscience.

SAVE the DATE !

Sept. 16, 2021 - Sept. 17, 2021

https://www.ccp-conference.cz/

Immersion training: aquatic animal facility/transgenesis in fish model
May 23, 2017

Immersion training in a center working on zebrafish and medaka models: Management of an aquatic facility - Injection and transgenesis

Regulatory training in English
May 23, 2017

Regulatory training designed for Anglophone students and researchers having a direct scientific responsibility for experimentation on animals.

The training program of 57 hours (over 7 days) is designed for Anglophone students and researchers having a direct scientific responsibility for experimentation on animals.
The teaching will focus on regulatory and legislative initiatives in animal experimentation in accordance with European and national regulation. It will also provide basic knowledge on the handling and use of laboratory rodents (animal welfare, ethics, cognition and behaviour, pain and stress, anaesthesia, analgesia, euthanasia, pathologies, zootechnics, anatomy, physiology, genetic engineering, phenotyping, imaging, alternative methods, biostatistics), as well as the selection criterion of an animal model.
This regulatory training is organized by CE2F-PRIM and held with the collaboration and the assistance of all the partner centers of CELPHEDIA. It will take place on July 3-11, 2016, in Marseille and might be limited to non-Francophone students and researchers working in a CNRS unit.
To register, create an account on the link  Registration

July 3, 2017 - July 11, 2017

2nd European school in mouse phenogenomics
May 20, 2017

International training focused on best practices in the use of the mouse model for biomedical research

Good practices: use of mouse models for biomedical and scientific research
Would you like to learn how to choose, create and analyze your best mouse model? Do you have a sufficient background in mouse functional genomics to lead at best your research?
This international training of excellence provides engineers, PhDs and researchers with an innovative program focused on best practices in the use of the mouse model biomedical and scientific research. Reach us and you will gain crucial skills required to use as best mutant mice and support you in your research!
It provides a wealth of information on good practices in the use of mouse model (standardized techniques, ethics, regulations, analysis, data and resources ...) to support attendees in their research.

The training takes place in Goersdorf-Liebfrauenberg (North of Alsace, France) from June 12 th to 16th.

June 12, 2017 - June 16, 2017

https://advanced-school.phenomin.eu/

Mouse model for diseases: approaches for phenotyping
Jan. 16, 2017

Training in ENGLISH: general framework to learn the basic knowledge and know-how in phenotyping

The training course is given in English and opened to graduate students (PhD), post-doctoral scientists, researchers and engineers. Alternating theoretical courses and practical workshops, this training aims to provide a general framework to learn the basic knowledge and know-how in phenotyping in order to answer “What’s wrong with my mice”
① Understand the interest of phenotyping to characterize gene function in mouse models,
② Learn about the scientific and ethical considerations in phenotyping,
③ Hear about the current web resources available,
④ Interact and consult with the experts on your own scientific project.
Attendees must have a basic knowledge in mouse physiology and to be able to handle mice.

Training "CNRS formation entreprises" in Illkirch (outskirts of Strasbourg)

March 14, 2017 - March 17, 2017

https://cnrsformation.cnrs.fr/stage-17232-Mouse-model-for-diseases-approaches-for-phenotyping.html?stage=17232&axe=78

Transgenic Rat Meeting Nantes
Jan. 3, 2017

The "Transgenic Rat" meeting will update information on techniques and models in transgenesis and genetic engineering.

This meeting is  organized by the “Transgenic rats” core facility, SFR François Bonamy, Biogenouest, TEFOR and IBiSA. The quality of the speakers is of the highest international level. The meeting will give the opportunity to update information on techniques and models in transgenesis and genetic engineering. It is intended for Master, PhD and medical students with a background in molecular biology and genetics as an introduction to future work in these rapidly developing areas of research. It is also intended for post-docs and scientists already working in certain of these fields and who are interested in expanding their knowledge on the potential applications of these new techniques to their models or in neighbouring pathophysiological models of analysis of genes or diseases using genetically modified animals. 

 

May 11, 2017 - May 12, 2017

http://www.trm.univ-nantes.fr/

Call 2016: ‘Mouse Models and Rare Diseases’
Jan. 1, 2017

Launch of the 3rd joint call "Mouse Models & Rare Diseases" by the Foundation for Rare Diseases and PHENOMIN

The French Foundation for Rare Diseases (Fondation maladies rares) and the French National Infrastructure PHENOMIN are pleased to launch their 3rd joint call for the creation and exploration of mouse models for rare diseases.
The call aims to give a significant boost to the development of mouse models, in order to
- gain a better understanding of the pathophysiological mechanisms involved in rare
diseases whose defective genes have been identified;
- test and validate therapeutic proofs of concept, at the pre-clinical in vivo level.
This call aims to create and caracterise consitutive (Ko) and conditional Knock-Out (cKO), Knock-In (KI) and transgenic (TG) mouse models in the field of rare diseases.
Upload the call fo proposal  
Submission on line
Submission deadline for proposals: February 9, 2017, 5:00 pm

Feb. 9, 2017

http://www.phenomin.fr/calls/current-call/

CTLS 2016 - Core Technologies for Life Science
Feb. 17, 2016

CTLS 2016 gathers scientists, decision makers and opinion leaders, involved in Core Technology Facilities of Life Science.

CTLS 2016, organized by EMBL, aims to bring together not only scientists, technicians and managers, but also decision makers and opinion leaders involved in Core Technology facilities and resource laboratories in all fields of Life Science.
Building on the success of CTLS 2014 in Paris, this meeting will be a unique opportunity to listen and discuss with colleagues and peers about challenges and solutions on all scientific, technological, managerial funding, educational and community building aspects of core facilities and infrastructures.
Keynote lectures will provide the big picture of this dynamic field, complimented by five plenary sessions comprising both oral and poster presentations, which will allow presenters and attendees to explore and discuss issues concerning European core facilities and infrastructures. There will also be ample opportunity for existing and prospective core facility networks or interest groups to organise satellite meetings.

Topics: transversal issues concerning, Core Facilities in Life Sciences (CFLS)

  • New technologies and methodologies developed by and with Life Science core facilities
  • Project & data management and quality control in and by Life Science core facilities
  • Core facility administrative, human resource and financial management
  • Teaching and training by and for Life Science core facilities
  • Building networks, communities and lobbies involving Life Science core facilities

CTLS meeting will be held in EMBL Heidelberg, Germany on June 12-15, 2016

Detailed description & registration

June 12, 2016 - June 15, 2016

http://www.embl.de/training/events/2016/CTL16-01/

2016 IMPC-INFRAFRONTIER meeting
Feb. 16, 2016

Investigating mouse models for biological for research

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about “Animal models for human diseases” and recent developments in mouse models phenotyping imaging.

We count on the attendance of 200 total participants every day including researchers of regional, national, European and international prominence and IMPC members and funders. The IMPC congress will be held on April 20-22, 2016 in Illkirch, France.

Description of the meeting
Detailled program

April 20, 2016 - April 22, 2016

PHENOMIN 6th call results
Feb. 4, 2016

The National Infrastructure PHENOMIN is pleased to announce the results of its 6th Call: Generation and Characterization of CreERT2 cell specific promoter driven deleter mouse lines.

The National Infrastructure PHENOMIN is pleased to announce the results of its 6th Call: Generation and Characterization of CreERT2 cell specific promoter driven deleter mouse lines. The Scientific Committee has selected 13 projects amongst 34 submitted projects from 20 PI. Consequently, 9 additional CreERT2 mouse lines will be generated by PHENOMIN team and will be made available as soon as possible for the scientific community. 4 CreERT2 mouse models been already generated by the European EUCOMMTOOLS consortium, will be further characterized.

You will find the details of the selected models on: http://www.phenomin.fr/calls/current-call/#phenomin-6th-call-results

To get more information, contact mutagenesis@igbmc.fr

"Microbiota and animal model" meeting
Feb. 4, 2016

During this meeting, experts will overview the current studies of the microbiota and its interaction with the host.

A "Microbiota and animal model" meeting is organized by the National Infrastructure PHENOMIN in Orléans on 2016, March 15th.
It has been proved that microbiota has a strong impact on development and human health. The studying methods of these bacterial populations and their interactions with host cells are in a process of development. Some methods focus on animal models enabling to compare the impact of various monitored flora on the phenotype or to measure this impact according the genotype of modified animals.
With input from experts, the goal of this meeting is to overview the current studies of the microbiota and its interaction with the host. It is also an opportunity to visit a rodent animal facility with more than 10 years of expertise in maintaining genetically modified animals with a monitored flora.
Program & Registration

March 15, 2016

http://www.celphedia.eu/site-media/docs/carton_invitation_TAAM_microbiote-12-01-2016.pdf

7th annual meeting of EFOR network
Feb. 4, 2016

As every year, the EFOR meeting will be dedicated to the various animal models used in scientific research.

The EFOR network is delighted to announce its 7th annual meeting in Paris on 2016, March 7th and 8th!
Thematic sessions will be held on the first day (March 7th): Models for studying stem cells from different tissues.Models for studying cerebrovascular accident. New imaging technologies and data processing tools. Genome editing in animals: ethical questions
The second day (March 8th) is devoted to parallel workshops, each dedicated to a model or a class of models: zebrafish, nematods, non-human primates, avian models, marine metazoa, lepidoptera, arthropoda, drosophila.
Preliminary program

To register, please contact djian@inaf.cnrs-gif.fr

March 7, 2016 - March 8, 2016

http://www.efor.fr/pages/post/?subject=events&id=43

The animal research reporting of in Vivo Experiments (ARRIVE) guidelines !
June 19, 2015

Benefits and challenges of applying the guidelines for the IMPC

The Animal Research Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future.

More information on PLOS biology

http://www.mousephenotype.org//

Communication of the European Commission on the 3rd European Citizen's initiative "STOP Vivisection"
June 4, 2015

Issue of the communication

The European Commission has issued a communication regarding the European Citizens’ Initiative “Stop Vivisection” which aimed to repeal to current European Directive 2010/63/EU (see our news published on  March 31, 2015).

In brief this initiative has been rejected by the EC and no changes would be applied to the actual legislation. In fact, despite the EC recognizes the concerns expressed by the proponents of this initiative, the Directive has been confirmed to be the best compromise between animal welfare enhancement and biomedical researches requiring animal experimentations.

For more information, please consult the European Commission conclusion on http://ec.europa.eu/environment/chemicals/lab_animals/pdf/vivisection/en.pdf

http://ec.europa.eu/environment/chemicals/lab_animals/pdf/vivisection/en.pdf

Transgenic Rat Meeting Nantes
May 21, 2015

A meeting to update information on techniques and models in transgenesis and genetic engineering.

This meeting is organized by the “Transgenic rats” core facility, SFR François Bonamy, Biogenouest, TEFOR and IBiSA. The quality of the speakers is of the highest international level. The meeting will give the opportunity to update information on techniques and models in transgenesis and genetic engineering.It is intended for Master, PhD and medical students with a background in molecular biology and genetics as an introduction to future work in these rapidly developing areas of research. It is also intended for post-docs and scientists already working in certain of these fields and who are interested in expanding their knowledge on the potential applications of these new techniques to their models or in neighbouring pathophysiological models of analysis of genes or diseases using genetically modified animals.
Program
Registration

July 2, 2015 - July 3, 2015

http://www.trm.univ-nantes.fr/

3rd Call fof joint research projects with IMPC
May 20, 2015

PHENOMIN is launching the 3rd Call for nomination in the frame of its partnership with IMPC

The National Infrastructure PHENOMIN PHENOMIN (CIPHE, ICS, TAAM) is pleased to announce the launch of the 3rd call for nomination in the frame of its partnership with the International Mouse Phenotyping Consortium (IMPC). This call for proposals is addressed to French-based research groups. It aims to establish and characterize mouse models: constitutive Knock-out (KO) and conditional Knock-Out (cKO). These knockout mice, together with the wealth of associated data, will serve as a valuable, freely available, resource for French researchers investigating gene function and human pathophysiology.

Since 2011, PHENOMIN has generated more than 150 models. In the frame of the IMPC more than 5,000 genes are already committed to the IMPC pipeline. Until the end of 2016, PHENOMIN will generate 100 additional knock-out lines. All these lines will be phenotyped through the standardized IMPC broad-based pipeline. Up to now, all models have been generated from ES mutant cells with conditional potential generated by the International Knockout Mouse Consortium (IKMC).

In the frame of this call, we have added constitutive knock-out models to be generated using CRISPR (clustered regularly interspaced short palindromic repeats) genome editing technology.

Conditions for eligibility:

  • For conditional and constitutive knock-out models: availability of at least 3 ES mutant cells with conditional potential generated by the IKMC consortium.
  • If no ES cells or less than 3 clones are available within the IKMC consortium, only the constitutive knock-out model will be generated using CRISPR genome editing technology.
  • To avoid any duplication within the IMPC, a gene already reserved by another center (i.e. already produced, or with production underway, or planned to be produced) will not be selected but the production state will be transferred to the requestor.

 

For all models that will be selected, please consider that:

  • As soon as the germ line transmission is confirmed, corresponding mouse lines will be available by the IMPC for your research as well as to any group which could be interested in.
  • The phenotyping data from comprehensive screen will be published on a public database and accessible to the whole scientific community.

To apply to this call for proposal, please fill in the application form.

Extended application deadline: June 15th, 2015.

Deadline: June 15, 2015

http://www.phenomin.fr/calls/current-call/#phenomin-5th-call-for-proposals

Regulatory training in English
May 4, 2015

Regulatory training in English for staff developing experimental procedures and projects

Regulatory training in ENGLISH for staff developing experimental procedures and projects (former level I)
The training program of 57 hours (over 7 days) is designed for Anglophone students and researchers having a direct scientific responsibility for experimentation on animals.
The teaching will focus on regulatory and legislative initiatives in animal experimentation in accordance with European and national regulation. It will also provide basic knowledge on the handling and use of laboratory rodents (animal welfare, ethics, cognition and behaviour, pain and stress, anaesthesia, analgesia, euthanasia, pathologies, zootechnics, anatomy, physiology, genetic engineering, phenotyping, imaging, alternative methods, biostatistics), as well as the selection criterion of an animal model.
This regulatory training is organized by CE2F-PRIM and held with the collaboration and the assistance of all the partner centers of CELPHEDIA. It will take place from September 7th-15th 2015, in Marseille and might be limited to non-Francophone students and researchers working in a CNRS unit.
To register, create an account on https://formations.primato.cnrs.fr/createAccount.php
Send all enquiries to formation-experimentation@ipbs.fr

 

Sept. 7, 2015 - Sept. 15, 2015

Results for the 2nd Joint Call « Murine Models and Rare Disease »
May 1, 2015

Research projects supported by the Scientific Committee

The "Fondation maladies rares", in partnership with the national infrastructure PHENOMIN, supports research projects dedicated to the development and to the study of murins models in the field of the rare diseases.

This joint call for projects "Mouse models and rare diseases" aims to give a significant boost to the development of mouse models, in order to :

  • gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified

  • test and validate therapeutic proofs of concept, at the pre-clinical in vivo level

This 2nd joined call supported the creation and the characterization of murins models of rare diseases: Knock-Out constitutive (KO)/ conditional (cKO), Knock-In (KI) and transgenic mice-.

The ad hoc Scientific Committee has supported 13 research projects.

Congratulations to the laureates !

http://fondation-maladiesrares.org/accueil